Natural medicinal ingredients induce tumor ferroptosis and related mechanisms
- 1 October 2021
- journal article
- review article
- Published by China Science Publishing & Media Ltd. in Journal of Zhejiang University (Medical Sciences)
- Vol. 50 (5) , 601-606
Abstract
铁死亡是一种铁依赖的程序性死亡，不同于传统的细胞死亡方式（如凋亡、焦亡、坏死、自噬），其特征是活性氧诱导脂质过氧化物堆积。铁死亡在肿瘤发生发展中发挥着重要的调控作用。最新研究表明，天然药物成分可通过谷胱甘肽/谷胱甘肽过氧化物酶4途径、铁代谢、脂质代谢等调控机制诱导肿瘤细胞铁死亡。研究发现了30多种天然药物成分具有诱导肿瘤细胞铁死亡的作用，且有多通路、多靶点的特点。本文综述了天然药物成分通过干预铁死亡抑制肿瘤的作用研究进展。Keywords
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