Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro
Authors:
- Diego Luís RibeiroDRDiego Luís Ribeiro
- Ana Rita Thomazela MachadoAMAna Rita Thomazela Machado
- Carla da Silva MachadoCMCarla da Silva Machado
- Patrick Wellington da Silva SantosPatrick Wellington da Silva Santos
- Alexandre Ferro AissaAAAlexandre Ferro Aissa
- Gustavo Rafael Mazzaron BarcelosGustavo Rafael Mazzaron Barcelos
- Lusânia Maria Greggi AntunesLALusânia Maria Greggi Antunes
- 1 June 2019
- journal article
- research article
- Published by Elsevier in Toxicology
- Vol. 422, 25-34
Abstract
No abstract availableKeywords
Funding Information
- Fundação de Amparo à Pesquisa do Estado de São Paulo
This publication has 66 references indexed in Scilit:
- Safety, Efficacy, and Mechanistic Studies RegardingCitrus aurantium(Bitter Orange) Extract andp‐SynephrinePhytotherapy Research, 2017
- Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exerciseJournal of Physiology and Biochemistry, 2017
- Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risksMolecular Nutrition & Food Research, 2017
- Cardiovascular Safety of Oral p‐Synephrine (Bitter Orange) in Healthy Subjects: A Randomized Placebo‐Controlled Cross‐over Clinical TrialPhytotherapy Research, 2016
- A Review of Natural Stimulant and Non‐stimulant Thermogenic AgentsPhytotherapy Research, 2016
- The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p‐SynephrinePhytotherapy Research, 2011
- Chronic inflammation and oxidative stress in human carcinogenesisInternational Journal of Cancer, 2007
- Hepatotoxicity of 3,4-methylenedioxyamphetamine and ?-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugatesArchives of Toxicology, 2004
- Identification of aneuploidy‐inducing agents using cytokinesis‐blocked human lymphocytes and an antikinetochore antibodyEnvironmental and Molecular Mutagenesis, 1989
- Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagensEnvironmental and Molecular Mutagenesis, 1988