Use of Topical Ice for Local Anesthesia for Intravitreal Injections

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Abstract
Topical anesthetic allergy is a rare but recognized entity for which incidence is difficult to calculate owing to the difference between a perceived and true allergic response. Allergic episodes attributed to topical anesthetics are typically adverse reactions, such as a vasovagal event, rather than the development of hypersensitivity.1 However, several articles place the likely incidence of topical anesthetic allergy at less than 1% of the general population.1