Quinolones affect thymidine incorporation into the DNA of human lymphocytes
Authors:
- A ForsgrenAFA Forsgren
- A K BerghABA K Bergh
- M BrandtMBM Brandt
- G HanssonGHG Hansson
Open Access
- 1 March 1986
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 29 (3) , 506-508
Abstract
The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.Keywords
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