Somatostatin receptor subtype 1 might be a predictor of better response to therapy in medullary thyroid carcinoma
Authors:
- 25 September 2017
- journal article
- research article
- Published by Springer Nature in Endocrine
- Vol. 58 (3) , 474-480
Abstract
Medullary thyroid carcinoma (MTC) is a malignant neoplasm of parafollicular cells. Because it is a neuroendocrine tumor, it has known somatostatin receptors (SSTRs). The actual frequencies of the SSTR subtypes and their potential influences (by binding with endogenous somatostatin) on MTC cell proliferation have not been fully elucidated to date. The present study evaluated the occurrence of SSTR subtypes 1, 2, 3 and 5 as well as the possible role that each subtype plays in the clinical evolution of patients with MTC.Keywords
Funding Information
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/203230/2016)
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