The discovery of the potent aurora inhibitor MK-0457 (VX-680)

This publication has 28 references indexed in Scilit:

• Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents
  Journal of Medicinal Chemistry, 2009
• Discovery of a potent and selective Aurora kinase inhibitor
  Bioorganic & Medicinal Chemistry Letters, 2008
• Molecular Basis of Drug Resistance in Aurora Kinases
  Chemistry & Biology, 2008
• Aurora A: Target Invalidated?
  Chemistry & Biology, 2008
• VX-680 Inhibits Aurora A and Aurora B Kinase Activity in Human Cells
  Cell Cycle, 2007
• Targeting aurora kinases as therapy in multiple myeloma
  Blood, 2007
• MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
  Blood, 2006
• Targeting Aurora Kinases for the Treatment of Prostate Cancer
  Cancer Research, 2006
• Aurora kinases: shining lights on the therapeutic horizon?
  Oncogene, 2005
• Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase
  Journal of Biological Chemistry, 2002