Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration
- 19 October 2020
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 83 (1) , 529-550
Abstract
The mammalian lung epithelium is composed of a wide array of specialized cells that have adapted to survive environmental exposure and perform the tasks necessary for respiration. Although the majority of these cells are remarkably quiescent during adult lung homeostasis, a growing body of literature has demonstrated the capacity of these epithelial lineages to proliferate in response to injury and regenerate lost or damaged cells. In this review, we focus on the regionally distinct lung epithelial cell types that contribute to repair after injury, and we address current controversies regarding whether elite stem cells or frequent facultative progenitors are the predominant participants. We also shed light on the newly emerging approaches for exogenously generating similar lung epithelial lineages from pluripotent stem cells.Keywords
This publication has 143 references indexed in Scilit:
- Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesisProceedings of the National Academy of Sciences, 2012
- Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airwaysProceedings of the National Academy of Sciences, 2012
- Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem CellsCell Stem Cell, 2012
- Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCsCell Stem Cell, 2012
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transitionProceedings of the National Academy of Sciences, 2011
- Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung AlveolarizationCell, 2011
- Novel Stem/Progenitor Cell Population from Murine Tracheal Submucosal Gland Ducts with Multipotent Regenerative PotentialStem Cells, 2011
- Basal cells as stem cells of the mouse trachea and human airway epitheliumProceedings of the National Academy of Sciences, 2009
- Stem cells are dispensable for lung homeostasis but restore airways after injuryProceedings of the National Academy of Sciences, 2009
- The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, EpitheliumCell Stem Cell, 2009