Cocaine-Induced Coronary-Artery Vasoconstriction

Authors:
  • RCRicardo G. Cigarroa
    Ricardo G. Cigarroa
  • CYClyde W. Yancy
    Clyde W. Yancy
  • JWJohn E. Willard
    John E. Willard
  • JPJeffrey J. Popma
    Jeffrey J. Popma
  • MSMichael N. Sills
    Michael N. Sills
  • WMWade McBride
    Wade McBride
  • AKAnatole S. Kim
    Anatole S. Kim
  • LHL. David Hillis
    L. David Hillis
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Abstract
Intranasal cocaine is used frequently as a local anesthetic during many rhinolaryngologic procedures. Although its "recreational" use in high doses has been associated with chest pain and myocardlal infarction, this association has not been established when cocaine is used in low doses as a topical anesthetic, and its effect on the coronary vasculature of humans is unknown.

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