Effects of prostaglandin‐E1 on ST segment elevation and regional myocardial blood flow during experimental myocardial ischaemia in dogs

Authors:
  • RRRudolph A. Riemersma
    Rudolph A. Riemersma
  • RTRichard C. Talbot
    Richard C. Talbot
  • AUAlex Ungar
    Alex Ungar
  • OMOle D. Mjøs
    Ole D. Mjøs
  • MOMichael F. Oliver
    Michael F. Oliver
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Abstract
The effects of prostaglandin E1 (PGE1) on myocardial ischaemia (as measured by epicardial ST segment changes), myocardial flow and substrate exchange has been studied in dogs. Myocardial ischaemia was induced by intermittent external clipping of a branch of the left anterior descending coronary artery.During occlusion with a continuous intravenous infusion of isoprenaline, elevated epicardial ST segments (∑ST), were raised to 46 ± 6 mV (mean ± SEM). Pretreatment with PGE1 reduced ∑ST to 34 ± 6 mV (P1 (P1 did not effect ∑ST or plasma FFA when infused intravenously or into the left atrium. Mean aortic blood pressure decreased from 131 ± 7 to 108 ± 10 (PGE1 i.v.) or 109 ± 8 mmHg (PGE1 i.a.) (P1 tended to decrease occlusion‐induced ST segment elevation.These results suggest that PGE1 can reduce isoprenaline‐stimulated myocardial ischaemia through its antilipolytic action but in the absence of catecholamine stimulation the main effect is to reduce blood pressure thereby counterbalancing any potentially beneficial effects on the ischaemic myocardium.

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