Role of Toxoplasma gondii IgG Avidity Testing in Discriminating between Acute and Chronic Toxoplasmosis in Pregnancy
- 24 August 2020
- journal article
- review article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 58 (9)
Abstract
Risk of mother-to-child transmission of Toxoplasma gondii during pregnancy is much greater in women who are exposed to primary T. gondii infection (toxoplasmosis) after conception compared to those who were exposed to the infection before conception. Therefore, laboratory tests that help classify recent primary toxoplasmosis are important tools for the management of pregnant women suspected to have T. gondii exposure. Detection of Toxoplasma IgM (Toxo IgM) is a sensitive indicator of primary toxoplasmosis, but the indicator specificity is low because sometimes natural IgM antibodies react with Toxoplasma antigens in the absence of the infection.Keywords
This publication has 64 references indexed in Scilit:
- Evaluation of the New Elecsys Toxo IgG Avidity Assay for Toxoplasmosis and New Insights into the Interpretation of Avidity ResultsClinical and Vaccine Immunology, 2012
- Maternal Serologic Screening to Prevent Congenital Toxoplasmosis: A Decision-Analytic Economic ModelPLOS Neglected Tropical Diseases, 2011
- Toxoplasma gondii: the changing paradigm of congenital toxoplasmosisParasitology, 2011
- Prospective Study of Congenital Toxoplasmosis Screening with Use of IgG Avidity and Multiplex Nested PCR MethodsJournal of Clinical Microbiology, 2011
- Development of Fully Automated Determination of Marker-Specific Immunoglobulin G (IgG) Avidity Based on the Avidity Competition Assay Format: Application for Abbott Architect Cytomegalovirus and Toxo IgG Avidity AssaysJournal of Clinical Microbiology, 2009
- Clinical utility of avidity assaysExpert Opinion on Medical Diagnostics, 2007
- Prenatal screening and diagnosis of congenital toxoplasmosis: a review of safety issues and psychological consequences for women who undergo screeningPrenatal Diagnosis, 2007
- Outcome of children after maternal primary Toxoplasma infection during pregnancy with emphasis on avidity of specific IgGThe Pediatric Infectious Disease Journal, 1995
- Studies on the Serodiagnosis of Toxoplasmic LymphadenitisClinical Infectious Diseases, 1995
- Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1The Pediatric Infectious Disease Journal, 1990