EXPERIMENTAL-MODELS OF BACTERIAL ARTHRITIS - A MICROBIOLOGIC AND HISTOPATHOLOGIC CHARACTERIZATION OF THE ARTHRITIS AFTER THE INTRA-ARTICULAR INJECTIONS OF NEISSERIA-GONORRHOEAE, STAPHYLOCOCCUS-AUREUS, GROUP-A STREPTOCOCCI, AND ESCHERICHIA-COLI

Authors:
  • DGDL GOLDENBERG
    DL GOLDENBERG
  • PCPL CHISHOLM
    PL CHISHOLM
  • PRPA RICE
    PA RICE
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  • 1 January 1983
    • journal article
    • research article
Abstract
The 1st reproducible experimental model of gonococcal arthritis, utilizing the intraarticular injection of virulent strains of N. gonorroeae into rabbits, is reported. An acute, purulent synovitis with a marked polymorphonuclear leukocyte infiltration developed during the first 24 h and persisted for at least 72 h, followed by a more chronic, mononuclear, proliferative synovitis. The histopathologic characteristics of this acute, then chronic, synovitis were comparable to that after the intraarticular injection of other bacteria. N. gonorrhoeae could not be recovered from the injected joints 24 h after inoculation; S. aureus, hemolytic streptococci, and E. coli were recovered for days to weeks after the intraarticular injection.

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