Synthesis, Characterization, and in vitro Antiproliferative Activity of [Salophene]platinum(II) Complexes

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Abstract
A series of methoxy‐ and fluorine‐substituted [salophene]platinum(II) complexes (salophene=N,N′‐bis(salicylidene)‐1,2‐phenylenediamine) were synthesized and characterized by 1H NMR spectroscopy and mass spectrometry. The structure was confirmed on the example of [5‐OCH3‐salophene]platinum(II) (4‐Pt) by crystal structure analysis. The cytotoxicity of all complexes against MCF‐7 cells showed strong dependence on the kind of substituent and its position on the salicylidene moiety, whereas 1‐Pt (H), 3‐Pt (4‐OCH3), and 6‐Pt (3‐F) exhibited high antiproliferative effects (IC501‐Pt acted as non‐DNA‐binding platinum anticancer drugs, as neither intercalation nor DNA covalent binding were detected.

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