L-WNK1 is required for BK channel activation in intercalated cells
- 7 July 2021
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 321 (2) , F245-F254
Abstract
When mice are placed on a high-K+ diet, genetic disruption of the long form of with no lysine kinase 1 (L-WNK1) in intercalated cells reduced relative apical/subapical localization of the large-conductance K+ channel, blunted large-conductance K+ channel currents in intercalated cells, and increased blood K+ concentration. These data confirm an in vivo role of L-WNK1 in intercalated cells in adaptation to a high-K+ diet.Keywords
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Funding Information
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK038470)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK110332)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK109038)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK054983)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK111542)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK098145)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK119252)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK079307)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK079307)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK079307)
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK038470)
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