Calcium Transient in Presynaptic Terminal of Squid Giant Synapse: Detection with Aequorin
Authors:
- 9 June 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4039) , 1127-1129
Abstract
Microinjection of aequorin, a bioluminescent protein sensitive to calcium, into the presynaptic terminal of the squid giant synapse demonstrated an increase in intracellular calcium ion concentration during repetitive synaptic transmission. Although no light flashes synchronous with individual presynaptic action potentials were detected, the results are considered consistent with the hypothesis that entry of calcium into the presynaptic terminal triggers release of the synaptic transmitter substance.Keywords
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