STUDIES ON THE PATHOGENESIS OF FEVER
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Open Access
- 1 August 1967
- journal article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 126 (2) , 385-394
Abstract
Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed.Keywords
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