Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression
Open Access
- 15 July 2025
- journal article
- Published by Elsevier in Kidney International
- Vol. 108 (5) , 827-847
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (P30DK127984)
- Dr. Robert C. and Veronica Atkins Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030_204187, 32350_214547, 323530_221874)
- Nutrition Obesity Research Center, University of North Carolina
- Université de Genève
This publication has 40 references indexed in Scilit:
- Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesisMolecular Metabolism, 2021
- Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2Kidney International Reports, 2021
- RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO miceJournal of Molecular Medicine, 2020
- Toward a better understanding of chronic kidney disease with complementary chromatographic methods hyphenated with mass spectrometry for improved polar metabolome coverageJournal of Chromatography B, 2019
- Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD PatientsEBioMedicine, 2017
- The hallmarks of mitochondrial dysfunction in chronic kidney diseaseKidney International, 2017
- Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis developmentNature Medicine, 2014
- Succinate: a metabolic signal in inflammationTrends in Cell Biology, 2014
- Glomerular hyperfiltration: definitions, mechanisms and clinical implicationsNature Reviews Nephrology, 2012
- Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver DiseaseCell Metabolism, 2011