Paecilosetin, a New Bioactive Fungal Metabolite from a New Zealand Isolate of Paecilomyces farinosus
- 1 May 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (5) , 810-811
Abstract
A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 μg/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.Keywords
This publication has 8 references indexed in Scilit:
- Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography–UV–mass spectrometry methodologyJournal of Chromatography A, 2003
- Novel Tetramic Acids and Pyridone Alkaloids, Militarinones B, C, and D, from the Insect Pathogenic Fungus Paecilomyces militarisJournal of Natural Products, 2003
- Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus CallusZeitschrift für Naturforschung C, 2002
- Antimicrobial, Antiviral and Cytotoxic Activity of New Zealand LichensThe Lichenologist, 1999
- Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.The Journal of Antibiotics, 1990
- Total synthesis of the Fusarium toxin equisetin: proof of the stereochemical relationship of the tetramate and terpenoid sectorsJournal of the American Chemical Society, 1989
- The yellow pigments of Beauveria species. Structures of tenellin and bassianinCanadian Journal of Chemistry, 1977
- Antibiotic Produced by Fusarium equiseti NRRL 5537Antimicrobial Agents and Chemotherapy, 1974