3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis

Authors:
  • JKJeffrey J. Kibby
    Jeffrey J. Kibby
  • IMIan A. McDonald
    Ian A. McDonald
  • RRRodney W. Rickards
    Rodney W. Rickards
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Abstract
The specific incorporation of 3-amino-5-hydroxybenzoic acid (2) into actamycin (1) by a Streptomycete culture establishes this amino-acid as a key intermediate in ansamycin and maytansinoid biosynthesis.