The impact of preimplantation genetic testing on the quality of life of people undergoing assisted reproduction treatment

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Abstract
Approximately 20% of infertility cases have a genetic origin. Preimplantation genetic testing (PGT) is an early prenatal diagnostic tool to prevent genetic disorders through embryo selection. Given its complexity, PGT requires a multidisciplinary approach, including psychosocial support, as infertility impacts mental health and overall well-being. Patients undergoing PGT often face prior miscarriages or IVF failures, elevating negative emotions and reducing quality of life. To compare affect levels, need for parenthood, and quality of life in IVF patients with and without PGT indications. This observational cross-sectional study included 375 patients divided into ‘PGT’ (n = 73) and ‘non-PGT’ ( n = 302) groups. Participants completed the Positive and Negative Affect Schedule (PANAS), Need for Parenthood scale, and Fertility Quality of Life tool (FERTIQOL). Group comparisons were conducted. The groups did not differ in terms of gender, type and cause of infertility, and psychotropic medication use. The PGT group reported higher negative emotions, lower quality of life compared to the non-PGT group. Both groups showed high levels of need for parenthood. Patients indicated for PGT require greater support and monitoring, experiencing a significant emotional impact from the outset of treatment.
Funding Information
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2019/17853-2)

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