Role of G Protein-coupled Orphan Receptors in Intestinal Inflammation

Authors:
  • MSMartin Storr
    Martin Storr
  • MZMarta Zielińska
    Marta Zielińska
  • JFJakub Fichna
    Jakub Fichna
Publisher website
Google Scholar
Abstract
A large number of proteins were classified into the family of G protein-coupled receptors (GPCRs). Based on their characteristic serpentine domain, they are called 7 TM receptors. Presently, their ligands and physiological functions remain unknown. In this review, we summarize what is known on these receptors and discuss the potential use of these orphan GPCRs (GPRs) in the induction or maintenance of remission in inflammatory bowel diseases. We focus on GPRs 30, 41, 43, 55, 119, and 120, where scientific evidence supports a potential role in intestinal inflammation.

This publication has 127 references indexed in Scilit: