Human Immunodeficiency Virus Infection, Bcl-2, p53 Protein, and Ki-67 Analysis in Ocular Surface Squamous Neoplasia
Authors:
- Amina MahomedAMAmina Mahomed
- Runjan ChettyRCRunjan Chetty
Open Access
- 1 May 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 120 (5) , 554-558
Abstract
OCULAR SURFACE squamous neoplasia (OSSN) is a rare condition, but interest in this disease has been revived in the literature through association with the human immunodeficiency virus (HIV) epidemic.1-5 The diagnosis of OSSN includes a spectrum of conditions ranging from mild squamous dysplasia of the conjunctiva through moderate dysplasia, carcinoma in situ (CIS), and, in the advanced stage, invasive squamous carcinoma.6 To the best of our knowledge, the relationship between OSSN and HIV infection has not yet been explored in Kwa-Zulu Natal, South Africa. Furthermore, whereas Dushku et al7 reported p53 expression to be confined to the limbal basal stem cells of pterygia and limbal tumors, other genetic and protein abnormalities in OSSN have not yet been reported.Keywords
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