Inhibition for gain modulation in the motor system
- 26 March 2022
- journal article
- review article
- Published by Springer Nature in Experimental Brain Research
- Vol. 240 (5) , 1295-1302
Abstract
Signatures of inhibition within the cortico-spinal pathway are frequently observed during action preparation in humans. Popular theoretical and computational models highlight a critical role for inhibition as the suppressor of motor system output, e.g., to withhold undesired action tendencies or to stop ongoing movements. However, inhibition frequently serves a modulatory role in non-motor systems. For example, in vision and somatosensory systems, inhibition can adjust the relationships between input and output, a computation referred to as gain modulation. Inhibition may modulate gain within the motor system as well. Changes in cortico-spinal inhibition observed during human behavior can reflect adjustments in motor system gain and may be sensitive to latent behavioral states. This review summarizes roles for inhibition in gain modulation, drawing principally on evidence from non-motor systems, and examines the hypothesis that homologous functions operate in the animal and human motor systems to facilitate action preparation.Keywords
This publication has 89 references indexed in Scilit:
- Activation of specific interneurons improves V1 feature selectivity and visual perceptionNature, 2012
- Dissociating the Role of Prefrontal and Premotor Cortices in Controlling Inhibitory Mechanisms during Motor PreparationJournal of Neuroscience, 2012
- Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortexThe Journal of Physiology, 2011
- Normalization as a canonical neural computationNature Reviews Neuroscience, 2011
- Broad Inhibition Sharpens Orientation Selectivity by Expanding Input Dynamic Range in Mouse Simple CellsNeuron, 2011
- Neurophysiology of dystonia: The role of inhibitionNeurobiology of Disease, 2011
- Evidence for Two Concurrent Inhibitory Mechanisms during Response PreparationJournal of Neuroscience, 2010
- Gating multiple signals through detailed balance of excitation and inhibition in spiking networksNature Neuroscience, 2009
- Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output FunctionsNeuron, 2009
- Role of Corticospinal Suppression during Motor PreparationCerebral Cortex, 2009