A Genome‐Wide Association Study of BMI in American Indians

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Abstract
Numerous studies have been done to understand genetic contributors to BMI, but only a limited number of studies have been done in nonwhite groups such as American Indians. A genome‐wide association study (GWAS) for BMI was therefore performed in Pima Indians. BMI measurements from a longitudinal study of 1,120 Pima Indians and 454,194 single‐nucleotide polymorphisms (SNPs) from the 1 million Affymetrix SNP panel were used (35% of SNPs were excluded due to minor allele frequency P < 4.94 × 10−7). For repeated measures analyses, the strongest associations for general and within‐family tests mapped to two different regions on chromosome 6 (rs9342220 (P = 1.39 × 10−6) and rs7758764 (P = 2.51 × 10−6), respectively). For maximum BMI, the strongest association for the general tests mapped to chromosome 4 (rs17612333; P = 1.98 × 10−6) and to chromosome 3 (rs11127958; P = 1.53 × 10−6) for the within‐family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity.

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