早期肺癌进展趋势的影响因素和CT研判
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Open Access
- journal article
- Vol. 21 (10) , 793-799
Abstract
不同类型的肺部结节具有不同的体积倍增时间（volume doubling time, VDT）。目前针对不同病理类型早期肺腺癌VDT的研究较少。本研究通过回顾性分析143例早期肺腺癌的影像资料，探讨早期肺腺癌的进展趋势及相关影响因素，为临床制订其随访策略提供参考。 依据2015版世界卫生组织肺肿瘤分类标准和第8版肿瘤肿瘤-淋巴结-转移（tumor-node-metastasis, TNM）分期标准，对143例早期肺腺癌进行分类及分期。参考修正版Schwartz公式计算不同病理类型肺腺癌的VDT。 143例早期肺腺癌中，有50例（34.97%）出现进展，多因素分析显示影响因素包括随访时间、结节大小、病理类型、结节类型和病理分期。附壁生长为主型肺腺癌（lepidic predominant adenocarcinoma, LPA）的VDT为（594±272）d，伴少量附壁生长成分浸润性腺癌的VDT为（520±285）d，完全浸润性腺癌的VDT为（371±183）d，3类进展性早期肺腺癌的VDT有统计学差异（P=0.044）。 在早期肺腺癌中，约有35%的肿瘤处于进展阶段，是否含有附壁生长成分是影响肿瘤进展速度的重要因素。Keywords
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