A Water‐Soluble Antimony‐Rich Polyoxometalate with Broad‐Spectrum Antitumor Activities

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Abstract
Herein, a giant Sb‐rich polyoxometalate (POM) {Sb21Tb7W56} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb‐rich POM has many interesting structural features and is a rare example of a soluble and water‐stable giant POM. Biomedical studies indicate that the Sb‐rich POM exhibits broad‐spectrum antitumor activity against various cancer cell lines by reactivating the P53‐dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb‐rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb‐rich POMs are promising candidates for the development of new anticancer drugs.
Funding Information
  • National Natural Science Foundation of China (22171045, 92161108, 21971039)
  • Natural Science Foundation of Fujian Province (2020J01438)

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