Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach
Open Access
Abstract
The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.Keywords
This publication has 49 references indexed in Scilit:
- Optimization and Characterization of Chitosan Films for Transdermal Delivery of OndansetronMolecules, 2013
- Alginates as biomaterials in tissue engineering2011
- Bioadhesive polymeric platforms for transmucosal drug delivery systems – a reviewTropical Journal of Pharmaceutical Research, 2010
- Studies on Optimizing In Vitro Transdermal Permeation of Ondansetron Hydrochloride Using Nerodilol, Carvone, and Limonene as Penetration EnhancersPharmaceutical Development and Technology, 2008
- Matrix-Type Transdermal Patches of Verapamil Hydrochloride: In Vitro Permeation Studies Through Excised Rat Skin and Pharmacodynamic Evaluation in RatsPharmaceutical Development and Technology, 2008
- Status of terpenes as skin penetration enhancersDrug Discovery Today, 2007
- In Vivo Skin Permeation of Sodium Naproxen Formulated in Pluronic F-127 Gels: Effect of Azone® and Transcutol®Drug Development and Industrial Pharmacy, 2005
- Transdermal Drug Delivery: Penetration Enhancement TechniquesCurrent Drug Delivery, 2005
- Polymers in drug deliveryCurrent Opinion in Chemical Biology, 2001
- Formulation Optimization of Indomethacin Gels Containing a Combination of Three Kinds of Cyclic Monoterpenes as Percutaneous Penetration EnhancersJournal of Pharmaceutical Sciences, 1994