Finite-Element Modeling of Cell Exposed to Harmonic and Transient Electric Fields
Authors:
- N. BuraisNBN. Burais
- F. BuretFBF. Buret
- L. NicolasLNL. Nicolas
- 26 March 2007
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Magnetics
- Vol. 43 (4) , 1773-1776
Abstract
The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite-element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results. Influences of membrane conductivity and frequency on the accuracy are studied. Optimization of transient waveforms is proposed for various shapes of cellsKeywords
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