ALDOSE REDUCTASE AND SORBITOL DEHYDROGENASE DISTRIBUTION IN SUBSTRUCTURES OF NORMAL AND DIABETIC RAT LENS

Authors:
  • JCJ G Collins
    J G Collins
  • CCC N Corder
    C N Corder
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  • 1 January 1977
    • journal article
    • research article
    • Vol. 16  (3) , 242-243
    • PMID:403152
Abstract
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, implicated in the pathogenesis of sugar cataracts. The levels of the 2 enzymes were determined with quantitative histochemical techniques in the epithelium, cortex and nucleus of normal and diabetic rat lenses. The ratio of activity of AR to SDH was nearly 50 to 1 in all substructures. This would strongly favor sorbitol accumulation and subsequent cataract formation.