Synthesis of Oxazoles through Copper‐Mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines
Authors:
- 9 October 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 51 (45) , 11367-11370
Abstract
A fragment-assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions (see scheme). The transformation is highly efficient with the removal of six hydrogen atoms, including the cleavage of four C(sp3)H bonds.Keywords
This publication has 116 references indexed in Scilit:
- Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization ReactionsAccounts of Chemical Research, 2011
- Das erste katalytische Tyrosinasemodell basierend auf einem einkernigen Kupfer(I)‐Komplex: Kinetik und MechanismusAngewandte Chemie, 2010
- The First Catalytic Tyrosinase Model System Based on a Mononuclear Copper(I) Complex: Kinetics and MechanismAngewandte Chemie International Edition, 2010
- O2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper μ‐η1:η1‐Peroxido ComplexAngewandte Chemie International Edition, 2010
- Palladium-Catalyzed Ligand-Directed C−H Functionalization ReactionsChemical Reviews, 2010
- A library of novel allosteric inhibitors against fructose 1,6-bisphosphataseBioorganic & Medicinal Chemistry, 2009
- Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond ActivationChemical Reviews, 2009
- Structure Elucidation at the Nanomole Scale. 1. Trisoxazole Macrolides and Thiazole-Containing Cyclic Peptides from the Nudibranch Hexabranchus sanguineusJournal of Natural Products, 2009
- Toluene and Ethylbenzene Aliphatic C−H Bond Oxidations Initiated by a Dicopper(II)-μ-1,2-Peroxo ComplexJournal of the American Chemical Society, 2009
- Multicopper Oxidases and OxygenasesChemical Reviews, 1996