Intravitreal Ceftriaxone in a Rabbit Model

Authors:
  • RSRobert K. Shockley
    Robert K. Shockley
  • WJWalter M. Jay
    Walter M. Jay
  • TFThomas R. Friberg
    Thomas R. Friberg
  • AAAdel M. Aziz
    Adel M. Aziz
  • JRJ. Peter Rissing
    J. Peter Rissing
  • MAMervat Z. Aziz
    Mervat Z. Aziz
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Abstract
• Ceftriaxone's toxic effects were assessed in albino rabbits after intravitreal injection. Doses up to 5 mg did not alter the B-wave amplitude. Following 7.5-and 20-mg doses, B-wave amplitude ratios were depressed at 24 hours and normal at seven and 14 days. A 50-mg dose caused a temporarily flat B-wave 24 hours after injection. At two weeks this ratio exhibited a moderate increase but remained 2 SDs below the mean preinjection ratio. Eyes receiving up to 20 mg were normal histologically at 14 days. A 50-mg dose induced generalized retinal edema and disruption of the retinal layers 24 hours after injection; at two weeks there were no histologic changes in the retina. Immediately after a 2-mg intravitreal injection, vitreous ceftriaxone levels were 1,345 ± 4.9 mg/L; by 72 hours they had decreased to 17.6 ± 1.4 mg/L. The mean peak aqueous level was 80.2 ± 12.2 mg/L at 72 hours.

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