Observations concerning the reactivity of normal and rheumatoid gamma globulins in rheumatoid serologic reactions

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Abstract
Samples of gamma globulin (F II) derived from sera of rheumatoid and non‐rheumatoid subjects behaved in a similar fashion either as a sensitizing agent or inhibitor in five separate tests for rheumatoid factor. Rheumatoid agglutinator and its gamma globulin reactant, or a precursor thereof, were found to coexist in all rheumatoid patients studied. The previous observation that gamma globulin has increased affinity for rheumatoid factor after heating to 63d̀ C. for 10 minutes was confirmed.

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