High Performance Liquid Chromatography Simultaneous Quantitation of Ketoprofen and Parabens in a Commercial GEL Formulation

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Abstract
A simple and rapid procedure for quantitation of Ketoprofen and parabens simultaneously in a commercial gel formulation by reversed phase high performance liquid chromatography was developed. The chromatographic analysis has been undertaken on a Hypersil ODS column by using a solvent mixture composed of acetonitrile-potassium dihydrogenphosphate buffer (pH=3.0) (40:60, v/v) isocratically with a U. V. detection at 254 nm. Ketoprofen related impurities and hydrolysis product of parabens are well resolved in these conditions and the method can be applied to quality control analysis of Ketoprofen and parabens in gel formulation.

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