Sustained release nifedipine formulations: Moment, Modelling and Simulation as pharmacokinetic analysis approach
Authors:
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 18 (2) , 187-202
Abstract
The bioequivalence of three sustained release nifedipine formulations designed in this laboratory, was assayed in rabbits by comparing their plasma time profiles to a reference (AdalatR retard). The analysis of data was performed by using the statistical moments as a measure of drug release. Results show a slowler absorption rate in the experimental formulations than in AdalatR retard, and not differences in the absorption extent. The composed one-compartment model, described for humans, showed to be also succesfull for rabbits.Keywords
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