Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers
Authors:
- Vesselina DelevaVDVesselina Deleva
- Xiaoming DengXDXiaoming Deng
- Adolfo SequeiraASAdolfo Sequeira
- Amanda PomarenskiAPAmanda Pomarenski
- Tim KlempanTKTim Klempan
- Neil ErnstNENeil Ernst
- Remi QuirionRQRemi Quirion
- Alain GrattonAGAlain Gratton
- Moshe SzyfMSMoshe Szyf
- Gustavo TureckiGTGustavo Turecki
Open Access
- 1 January 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 66 (1) , 22-32
Abstract
Suicide is most often associated with depressed mood and hopelessness and is a leading cause of death in many regions of the world.1-6 Although much of the effort to understand the biological mechanisms of these mood states has centered on neuronal processes, some recent studies have suggested that astroglial dysfunction may play an important role.7-10 Astrocytes, the most prevalent cell type in the central nervous system, are involved in synaptic communication11; express receptor subtypes for serotonin, γ-aminobutyric acid, glutamate, and dopamine12; and are capable of rapid, long-range signaling throughout the brain.13 The role of astrocytes in brain homeostasis, metabolism, and injury has been extensively documented.14 More recently it has become clear that astrocytes play an important role in many brain functions15 and may be involved in mood and other neurological disorders.16Keywords
This publication has 1 reference indexed in Scilit:
- Reelin promoter hypermethylation in schizophreniaProceedings of the National Academy of Sciences, 2005