G Protein Subunit Gα 13 Binds to Integrin α IIb β 3 and Mediates Integrin “Outside-In” Signaling

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Abstract
Integrin G Protein: Adhesion molecules, known as integrins, are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. Gong et al. (p. 340 ) show that they do so in part by partnering with a signal-transducing protein called Gα 13 . Such α subunits of heterotrimeric guanine nucleotide-binding proteins are well known for transducing signals from the large class of G protein–coupled receptors, but were not known to work with integrins. Gα 13 appears to interact directly with the integrin α IIb β 3 and to transmit signals that regulate cell spreading.

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