Immunologic Reactions of Bronchial Tissues in Asthma
Authors:
- Mary Lou CallerameMCMary Lou Callerame
- John J. CondemiJCJohn J. Condemi
- Milton G. BohrodMBMilton G. Bohrod
- John H. VaughanJVJohn H. Vaughan
- 4 March 1971
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 284 (9) , 459-464
Abstract
Bronchial tissues obtained from 18 patients with bronchial asthma showed thickened basement membranes that stained positively for immunoglobulins in five of 11 biopsy specimens and six of seven autopsy specimens. Complement (C3) was identified in the deposit in three cases. IgM was the immunoglobulin most frequently seen. Similar studies in controls demonstrated no basement-membrane thickening, but fluorescence with antiserum to IgG was found in 10 per cent and to IgM in 3 per cent.Keywords
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