Functions of Plexins/Neuropilins and Their Ligands during Hippocampal Development and Neurodegeneration
Open Access
Abstract
There is emerging evidence that molecules, receptors, and signaling mechanisms involved in vascular development also play crucial roles during the development of the nervous system. Among others, specific semaphorins and their receptors (neuropilins and plexins) have, in recent years, attracted the attention of researchers due to their pleiotropy of functions. Their functions, mainly associated with control of the cellular cytoskeleton, include control of cell migration, cell morphology, and synapse remodeling. Here, we will focus on their roles in the hippocampal formation that plays a crucial role in memory and learning as it is a prime target during neurodegeneration.Keywords
Funding Information
- Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya (SGR2017-648)
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España (BFU2015-67777-R)
- Spanish prion network (AGL2015-71764-REDT)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (PRY-2016-2, MFDEND, and PRY-2018-2)
This publication has 151 references indexed in Scilit:
- Class 3 Semaphorin Mediates Dendrite Growth in Adult Newborn Neurons through Cdk5/FAK PathwayPLOS ONE, 2013
- Development and Evolution of the Human NeocortexCell, 2011
- Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNSNature, 2009
- Semaphorin function in neural plasticity and diseaseCurrent Opinion in Neurobiology, 2009
- Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: Implications for genesis of neurodevelopmental disordersSchizophrenia Research, 2008
- Gating of Sema3E/PlexinD1 Signaling by Neuropilin-1 Switches Axonal Repulsion to Attraction during Brain DevelopmentNeuron, 2007
- Guidance of myocardial patterning in cardiac development by Sema6D reverse signallingNature Cell Biology, 2004
- Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural developmentJournal of Neurobiology, 2004
- Semaphorin 7A promotes axon outgrowth through integrins and MAPKsNature, 2003
- The Semaphorin 4D receptor controls invasive growth by coupling with MetNature Cell Biology, 2002