Background: Severe mitral regurgitation (MR) causes remodeling of the left ventricle (LV). After surgical mitral valve repair (MVR) reverse remodeling of the LV has been observed. Aim of this study was to assess if percutaneous MVR with the MitraClip system can also induce a reverse LV remodeling. Patients and methods: We prospectively included 33 consecutive patients with symptomatic moderate-to-severe MR and high perioperative risk undergoing percutaneous MVR. Patients underwent transthoracic echocardiography (LV volumes, LV stroke volume, ejection fraction, diameter of mitral annulus) and strain analysis (global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS)) by speckle-tracking echocardiography and by MRI prior to the procedure and three months after the procedure. Results: Three months after MitraClip procedure reverse LV remodeling was documented by a significant reduction of LV endsystolic (116.2±71.0 mL to 102.9±58.3 mL, pConclusions: Successful percutaneous MRV not only leads to an improvement of MR, but additionally allows a reverse LV remodeling within 3 months, which might contribute to the symptomatic and prognostic success in these patients.