Abdominal Adiposity Is Associated With Elevated C-Reactive Protein Independent of BMI in Healthy Nonobese People
Authors:
- Simona MaioneSMSimona Maione
- Lidia PattiLPLidia Patti
- Olga VaccaroOVOlga Vaccaro
Open Access
- 8 July 2009
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 32 (9) , 1734-1736
Abstract
OBJECTIVE: There is debate over the most appropriate adiposity markers of obesity-associated health risks. We evaluated the relationship between fat distribution and high-sensitivity C-reactive protein (hs-CRP), independent of total adiposity. RESEARCH DESIGN AND METHODS: We studied 350 people with abdominal adiposity (waist-to-hip ratio [WHR] ≥0.9 in male and ≥0.85 in female subjects) and 199 control subjects (WHR 3 mg/dl). CONCLUSIONS: In nonobese people, moderate abdominal adiposity is associated with markers of subclinical inflammation independent of BMI.Keywords
This publication has 13 references indexed in Scilit:
- Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive ProteinNew England Journal of Medicine, 2008
- General and Abdominal Adiposity and Risk of Death in EuropeNew England Journal of Medicine, 2008
- C‐reactive protein and coronary heart disease: a critical reviewJournal of Internal Medicine, 2008
- BMI vs. Waist Circumference for Identifying Vascular RiskObesity, 2008
- Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative StressCirculation, 2007
- Inflammatory Markers and the Risk of Coronary Heart Disease in Men and WomenNew England Journal of Medicine, 2004
- C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult womenInternational Journal of Obesity, 2001
- The relation of body fat mass and distribution to markers of chronic inflammationInternational Journal of Obesity, 2001
- Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by GlucocorticoidThe Journal of Clinical Endocrinology & Metabolism, 1998
- Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytesFEBS Letters, 1989