Safety and Efficacy of Enoxaparin vs Unfractionated Heparin in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Who Receive Tirofiban and AspirinA Randomized Controlled Trial

Authors:
  • JLJames A. de Lemos
    James A. de Lemos
  • HWHarvey D. White
    Harvey D. White
  • FVFreek W. A. Verheugt
    Freek W. A. Verheugt
  • DADiego Ardissino
    Diego Ardissino
  • PDPeter M. DiBattiste
    Peter M. DiBattiste
  • JPJoanne Palmisano
    Joanne Palmisano
  • DBDavid W. Bilheimer
    David W. Bilheimer
  • SSSteven M. Snapinn
    Steven M. Snapinn
  • KRKaren E. Ramsey
    Karen E. Ramsey
  • LGLaura H. Gardner
    Laura H. Gardner

Abstract
In recent years, several classes of antiplatelet and antithrombotic agents have been shown to be safe and effective therapies for patients with non–ST-segment elevation acute coronary syndromes (ACS).1 Guidelines from the American College of Cardiology, American Heart Association, and European Society of Cardiology recommend early use of small-molecule platelet glycoprotein IIb/IIIa inhibitors with unfractionated heparin in high-risk patients with non–ST-segment elevation ACS, particularly if an invasive approach is planned.2,3

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