The Opossum as an Animal Model for Studying Radiation Esophagitis

Authors:
  • MNMargaret G. Northway
    Margaret G. Northway
  • HLHerman I. Libshitz
    Herman I. Libshitz
  • JWJohn J. West
    John J. West
  • HWH. Rodney Withers
    H. Rodney Withers
  • AMArun K. Mukhopadhyay
    Arun K. Mukhopadhyay
  • BOBarbara M. Osborne
    Barbara M. Osborne
  • ISIrene A. Szwarc
    Irene A. Szwarc
  • GDGerald D. Dodd
    Gerald D. Dodd
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Abstract
Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, four animals received 60Co radiation of various doses; two served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography, and manometry were performed. Esophagitis developed at one week in irradiated animals. Opossums receiving 17.5, 20, and 22.5 Gy (1,750; 2,000; and 2,250 rad) became anorexic one week postirradiation, and abnormal motility subsequently developed. The controls and the animal receiving 15 Gy (1,500 rad) remained normal. Histological changes in the irradiated opossum esophagus resembled those found in humans.