A Direct Intermolecular Cross‐Benzoin Type Reaction: N‐Heterocyclic Carbene‐Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones

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Abstract
A direct intermolecular cross‐benzoin‐type condensation catalyzed by an N‐heterocyclic carbene has been developed. The cross‐coupling of commercially available aromatic aldehydes and trifluoromethyl ketones results in α‐hydroxy‐α‐trifluoromethyl ketones bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.

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