Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors
- 1 September 2019
- journal article
- conference paper
- Published by Elsevier in Bioorganic Chemistry
- Vol. 90, 103045
Abstract
No abstract availableKeywords
Funding Information
- National Science Foundation (CHE 03 42251)
- Florida Institute of Technology
This publication has 47 references indexed in Scilit:
- Liquid chromatography–tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasmaJournal of Chromatography B, 2013
- Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domainBiochemical Journal, 2012
- Design, Synthesis and Antiproliferative Activity of Novel 2-Substituted-4-amino-6-halogenquinolinesMolecules, 2012
- Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitorsBioorganic & Medicinal Chemistry, 2011
- Synthesis and antitumor activity of novel 6-aryl and 6-alkylpyrazolo[3,4-d]pyrimidin-4-one derivativesEuropean Journal of Medicinal Chemistry, 2010
- Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: Synthesis and biological evaluationBioorganic & Medicinal Chemistry, 2010
- Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activityBioorganic & Medicinal Chemistry, 2010
- A review of erlotinib – an oral, selective epidermal growth factor receptor tyrosine kinase inhibitorExpert Opinion on Pharmacotherapy, 2009
- Gefitinib (ZD1839, Iressa®) in non‐small‐cell lung cancer: a review of clinical trials from a daily practice perspectiveFundamental & Clinical Pharmacology, 2005
- Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione AnalogueMolecules, 2000