Aggregation of steroidal lariat ethers: the first example of nonionic liposomes (niosomes) formed from neutral crown ether compounds

Authors:
  • LELourdes E. Echegoyen
    Lourdes E. Echegoyen
  • JHJeanette C. Hernandez
    Jeanette C. Hernandez
  • AKAngel E. Kaifer
    Angel E. Kaifer
  • GGGeorge W. Gokel
    George W. Gokel
  • LELuis Echegoyen
    Luis Echegoyen
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Abstract
N-(3-Dihydrocholesteryloxycarbonylmethyl)-(1) and N-(3-cholesteryloxycarbonylmethyl)-1-aza-4,7,10,13-tetraoxa-cyclopentadecane (2) aggregate in water to from the first examples of niosomes based on amphiphiles having an uncomplexed crown ether residue as the head group.