Serum Level of Complement Factor D in Systemic Lupus Erythematosus—an Indicator of Glomerular Filtration Rate

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Abstract
Serum levels of complement factor D, a low molecular weight (LMW) protein, were high and inversely correlated with glomerular filtration rate (GFR) determined in 19 patients with lupus glomerulonephritis (LGN). Factor D was significantly closer correlated with S‐creatinine than were two other LMW proteins, β2‐microglobulin and γ‐trace in 22 LGN patients. Close correlations between each of the LMW proteins and S‐creatinine were found in patients with a non‐inflammatory disorder, polycystic kidney disease. Slightly increased β2‐microglobulin concentrations were found in 15 of 20 systemic lupus erythematosus (SLE) patients without renal involvement, while factor D and γ‐trace showed normal values in most of these patients. The findings imply that serum concentrations of complement factor D in SLE are mainly determined by the GFR.

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