From Omic Layers to Personalized Medicine in Colorectal Cancer: The Road Ahead
Open Access
Abstract
Colorectal cancer is a major health concern since it is a highly diagnosed cancer and the second cause of death among cancers. Thus, the most suitable biomarkers for its diagnosis, prognosis, and treatment have been studied to improve and personalize the prevention and clinical management of colorectal cancer. The emergence of omic techniques has provided a great opportunity to better study CRC and make personalized medicine feasible. In this review, we will try to summarize how the analysis of the omic layers can be useful for personalized medicine and the existing difficulties. We will discuss how single and multiple omic layer analyses have been used to improve the prediction of the risk of CRC and its outcomes and how to overcome the challenges in the use of omic layers in personalized medicine.Keywords
This publication has 80 references indexed in Scilit:
- CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancerGenome Research, 2013
- HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin StructurePLOS ONE, 2013
- Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancerMedical Oncology, 2013
- Genome-wide multi-omics profiling of colorectal cancer identifies immune determinants strongly associated with relapseFrontiers in Genetics, 2013
- Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal CancersCancer Research, 2011
- Colorectal Cancers with Microsatellite Instability Display Unique miRNA ProfilesClinical Cancer Research, 2011
- MicroRNA profiling differentiates colorectal cancer according to KRAS statusGenes, Chromosomes and Cancer, 2011
- MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?Cancer Epidemiology, Biomarkers & Prevention, 2011
- A Large Prospective Study of Meat Consumption and Colorectal Cancer Risk: An Investigation of Potential Mechanisms Underlying this AssociationCancer Research, 2010
- Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of RadiologyCA: A Cancer Journal for Clinicians, 2008