Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications
- 17 October 2011
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Soft Matter
- Vol. 7 (23) , 11259-11266
Abstract
In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.Keywords
This publication has 47 references indexed in Scilit:
- Glycerol based polyether-nanogels with tunable properties via acid-catalyzed epoxide-opening in miniemulsionReactive and Functional Polymers, 2011
- Hyperbranched polyglycerols on the nanometer and micrometer scaleBiomaterials, 2011
- Chitosan-based responsive hybrid nanogels for integration of optical pH-sensing, tumor cell imaging and controlled drug deliveryBiomaterials, 2010
- Synthesis, Reductive Cleavage, and Cellular Interaction Studies of Biodegradable, Polyglycerol NanogelsAdvanced Functional Materials, 2010
- Functional dendritic polymer architectures as stimuli-responsive nanocarriersBiochimie, 2010
- Polyglycerol nanogels: highly functional scaffolds for biomedical applicationsSoft Matter, 2010
- Emerging applications of stimuli-responsive polymer materialsNature Materials, 2010
- Dendritic Polyglycerols for Biomedical ApplicationsAdvanced Materials, 2009
- Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating PropertiesAngewandte Chemie International Edition, 2009
- Functional Nanoparticles from Dendritic Precursors: Hierarchical Assembly in MiniemulsionMacromolecules, 2008