Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
Open Access
- 27 February 2023
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 24 (5) , 4635
Abstract
Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients’ lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and β-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules.Keywords
Funding Information
- Italian Cystic Fibrosis Foundation (FFC#5/2022, FFC#18/2021)
- Italian Cystic Fibrosis Foundation (FFC#5/2022, FFC#18/2021)
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