THE EFFECT OF OESTROGENS AND ANTI-OESTROGENS ON DECIDUOMA FORMATION IN THE RAT

Authors:
  • GSG. M. Stone
    G. M. Stone
  • CEC. W. Emmens
    C. W. Emmens
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Abstract
SUMMARY The maximum sensitivity to single subcutaneous injections of oestradiol or dimethylstilboestrol (DMS) occurred approximately 60 hr. after the induction of pseudopregnancy. Injection of the two compounds together at this time showed only an additive effect, suggesting that DMS was acting as a pro-oestrogen rather than as an anti-oestrogen. Single subcutaneous injections of progesterone were unable to reverse completely the inhibitory action of oestradiol; 17-ethyl-19-nortestosterone was more effective. Low doses of MER-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenylethanol) slightly reduced decidual growth while higher doses, which were oestrogenic, inhibited deciduoma formation and decidual growth. In combination with oestradiol low doses of MER-25 antagonized the inhibitory action of oestradiol.