Benzodiazepine Inhibition of the Calcium-Calmodulin Protein Kinase System in Brain Membrane

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Abstract
Benzodiazepines inhibit Ca 2+ -calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca 2+ -calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinguishable by several criteria from the previously described high-affinity benzodiazepine receptor.

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